A motorcyclist has been taken to hospital with serious injuries following a crash, police said.
Devon and Cornwall Police said emergency services were called to Victoria Road, Plymouth, following a report of a motorbike in collision with a wall at about 09:00 BST.
Police said Highways assisted with the road closure on Victoria Road to allow officers to conduct a thorough investigation.
"Emergency services attended the scene and the male rider was taken to Derriford Hospital where his injuries have been deemed as life changing," police said.
"Officers from the Roads Policing Team are appealing for any witnesses in the area that may have seen the collision, have dash camera or CCTV footage to come forward."
A spokesperson for South Western Ambulance NHS Foundation Trust said it sent two double-crewed land ambulances, an air ambulance, an operations officer and a specialist paramedic to the scene.
They added: "We conveyed one patient by land ambulance to Derriford Hospital."